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KMID : 0376219790160010055
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Chonnam Medical Journal
1979 Volume.16 No. 1 p.55 ~ p.63
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Comparative studies on the antibiotic susceptibility of Pseudomonas aeruginosa strains isolated from urban and rural areas
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Abstract
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Pseudomonas aeruginosa has recently been attracting much attention of microbiologists because of the organism´s rapidly replacing Staphylococcus aureus as a nosocomial agent due to its natural drug-resistance and opportunistic properties.
In our country the indiscriminate usage of antibiotics is supposed to be more prevailing in urban inhabitants than in rural ones. The comparison of drug resistance patterns of the organisms isolated from the two areas is, therefore, expected to reveal some rewarding differences in the MIC distribution frequencies, which may be applied eventually to the appropriate dosing of antibiotics.
Thirty-three strains of Ps. aeruginosa isolated from Kwangju area and 27 strains isolated from several rural areas were compared as to their antibiotic susceptibility patterns, utilizing the cumulative percentage of strains inhibited at various MIC.
Most of the isolated strains showed a high degree of resistance against EM and no particular difference was observed between the urban and rural strains. However, the isolates in general were highly susceptible to GM, more than 90% being inhibited at MIC of 16 pg/tat, and also a distinct difference in the GM resistance pattern was observed between the two areas, the number being 60% higher in urban isolates at MIC 4 ,ug/mt. In contrast to GM, the organisms isolated in urban areas were generally more resistant to KM and more than 30% survived at such a high MIC as 256 py/mt. A moderate suscetibility pattern was observed in CB and 470/0 difference was noticed at MIC 16pg/mt between urban and rural isolates. In other drugs, CB and CD, no particular difference between the two groups of isolates was noticed.
Thus, it may be concluded that urban isolates appeared to have the tendancy of resistance to antibiotics than rural ones. It may be, however, also true that without practically examining the potency of each drug no strain isolated anywhere could be treated as more susceptible or pot.
Immunotyping and pyocin typing were also carried out. No particular relationship was, however, observed between the types and drug resistance patterns.
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